Chris Masterjohn presents at the Ancestral Health Symposium that it is the oxidation of the lipids and cholesterol that is what is damaging to heart disease.
Lipids gets oxidized and LDL goes from large fluffy to the more dangerous small dense type as they stay in the blood longer and more likely to get oxidized. Why causes the lipids to stay in the blood? Because the LDL receptors of the cells are not taking them up fast enough or low thyroid hormones.
He says that having nutritional abundance would offset the oxidation process.